F-Box Only Protein 7 Gene in Parkinsonian-Pyramidal Disease
نویسندگان
چکیده
منابع مشابه
The role of F-box only protein 31 in cancer
F-box only protein 31 (FBXO31), initially identified in 2005, is a novel subunit of the S-phase kinase associated protein 1-Cullin 1-F-box ubiquitin ligase. As with other F-box proteins, FBXO31 may interact with several proteins to promote their ubquitination and subsequent degradation in an F-box-dependent manner. It has been revealed that FBXO31 serves a crucial role in DNA damage response an...
متن کاملIdentification of F-box only protein 7 as a negative regulator of NF-kappaB signalling
The nuclear factor κB (NF-κB) signalling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear translocation of the NF-κB transcription factor family member p65 as a read-out, we screened a synthe...
متن کاملGenetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease.
Parkinson’s disease (PD) is a common neurodegenerative disease. It is characterized by the presence of cardinal motor signs, including tremor at rest, rigidity, bradykinesia, and loss of postural reflexes [1]. There is increasing evidence that genetic factors are implicated in the etiology of PD. To date, at least 18 genetic loci and 13 disease-related genes have been identified [1]. Previous s...
متن کاملF-box/LRR-repeat protein 7 is genetically associated with Alzheimer’s disease
OBJECTIVE In the context of late-onset Alzheimer's disease (LOAD) over 20 genes have been identified but, aside APOE, all show small effect sizes, leaving a large part of the genetic component unexplained. Admixed populations, such as Caribbean Hispanics, can provide a valuable contribution because of their unique genetic profile and higher incidence of the disease. We aimed to identify novel l...
متن کاملF-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with a severe form of autosomal recessive juvenile-onset Parkinson's disease (PD) (PARK 15). Here we demonstrated that wild-type (WT) FBXO7 is a stress response protein and it can play both cytoprotective and neurotoxic roles. The WT FBXO7 protein is vital to cell mitophagy and can facilitate mitophagy to prote...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2013
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2013.572